Zynamite® - a natural exercise-mimetic ingredient

A recent study has confirmed an unprecedented scientific finding, which further supports the benefits of Zynamite® in the development of sports activity and its potential to enhance muscle performance.

Nektium is pleased to share an exciting discovery about one of our flagship ingredients, Zynamite® (see the publication), which is also featured in Nutrients.

As you know, previous studies (1,2,3) carried out with Zynamite PX® (Zynamite® in combination with Quercetin) provided convincing scientific evidence showing improvements in several parameters of sports performance and recovery such as: increases peak and mean power, increases V02 max and brain oxygenation, reduces muscle fatigue, enhances acceleration of recovery, contributes to pain reduction, supports the reduction of muscle damage. As a result of this line of research, which has remained active in coordination with our R&D department, we have been able to continue studying many of these samples to finally understand the mechanisms of action that reinforce our confidence about the potential of Zynamite® in the sports category, providing us with new knowledge to advance in the search for new applications.

The study reveals that Zynamite PX® triggers a biochemical response in skeletal muscle cells at rest, similar to that which occurs during physical exercise. This discovery is truly remarkable, as it provides an explanation at the biomolecular level for the benefits we already knew about Zynamite® in sports.

In addition, researchers have shown that Zynamite® modifies signaling in muscle cells during intense exercise, resulting in a decrease in the activity of stressor enzymes for improved muscle performance.

These results are promising, as they indicate that Zynamite® may not only help preserve muscle mass, but also reduce fatigue and increase muscle recovery capacity.

Importantly, this study is only the first chapter of ongoing research, which opens up an exciting avenue for the use of Zynamite® for a variety of purposes. We are excited about the implications this could have in the field of sports and muscle health in general.

We will be delighted to have a short introduction call to get into a more deep detailed explanation of these new findings.

1. _{Gelabert-Rebato, et al. A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women. Nutrients, 11 (11), 2592 (2019).}
2. _{Martin-Rinco, M., et al. Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery After Strenuous Damaging Exercise. Nutrients (2020).}
3. _{Gelabert-Rebato, M. et al. Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2 peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans. Frontiers in Physiology, 9, 740 (2018).}